Table 2.

Results of between-group meta-analyses based on type of vaccine and disease category

Sub-group	Comparison	No. studies	No. participants	No. events	Meta-analysis			Heterogeneity
					Effect size (%)	95% Confidence interval (%)	p value	I2 (%)	p value
Type of vaccine pair-wised	mRNA vs. inactivated	38	23,028	2409	6.58	4.57–8.89	0.0036	98.2	0
	mRNA vs. vector	33	21,124	2468	6.60	4.34–9.19	0.0788	97.9	0
	Vector vs. inactivated	17	13,538	651	1.37	0.11–3.51	0.5969	95.8	< 0.0001
Disease category	Rheumatologic and musculoskeletal	34	43,894	3020	7.25	5.2–9.58	< 0.0001	96.1	0
	Gastroenterological	6	9832	1395	7.86	1.61–18.11		99.7
	Dermatological	6	2386	138	4.81	1.29–9.70		89.7
	Neurological	16	12,212	473	2.62	1.49–4.04		95.2
	Nephrological	2	93	27	26.66	8.16–50.59		82.1
	Hematologic	8	1186	150	14.12	3.77–28.39		95.0

Statistically significant values (p < 0.05) are in bold