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. 2024 Jan 17;21:23. doi: 10.1186/s12974-023-02969-6

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Strong correlation between intraepidermal nerve fibres and associated Schwann cells in murine plantar skin. Male and female mice underwent chronic constriction injury (CCI) or sham surgery. Hind paw foot pads were harvested 7 days after surgery and intraepidermal nerve fibre density (IENFD), and the density of intraepidermal Schwann cell processes were determined. A IENFD and B associated Schwann cell numbers are plotted (Welch’s ANOVA and Dunnett’s tests, n_Sham = 6, n_{CCI IL} = 8, n_{CCI CL} = 8). C Pearson correlation between IENFD and Schwann cell process density in all skin samples (n = 22). Data are shown as mean ± SD. CL: contralateral; IL: ipsilateral