Table 5.
Summary of ATPS-based biomaterials with complex structures for drug delivery.
| ATPS-based biomaterial used for drug delivery | Delivered component | The ingredient of the ATPSs | The advantage of the materials obtained | Ref. |
|---|---|---|---|---|
| (1) CaCO3/PEs composite microcapsules | BSA | PEG (8 kDa) + DEX (500 kDa) | Showing pH-triggered release ability | 21 |
| (2) (collagen + pectin)/chitosan microcapsule | Anthocyanin cations | Chitosan (30 kDa) + pectin (149.6 kDa) and collagen (<5 kDa) | The release of loaded anthocyanins was pH-dependent, and its delayed release was realized with the increase in pH | 113 |
| (3) PEGDA microcapsules | FITC-DEX | PEGDA (0.575 and 10 kDa) + DEX (450–650 kDa) | Achieving precise drug delivery by real-time adjustment of FUS parameters | 114 |
| (4) PSS/PDDA microcapsules | PDGF-BB molecules and streptavidin | PEG (8 kDa) + DEX (500 kDa) | The release of loaded molecules can be controlled with the use of external stimuli, such as pH or temperature | 115 |
| (5) PSS/PDDA microcapsules | Trypsin | PEG (8 kDa) + DEX (500 kDa) | The enzyme was wrapped around the core of the microcapsule and released when pH or osmotic pressure changes | 116 |
| (6) Alginate microcapsules | GOX + HRP | PEG (8 kDa) + DEX (500 kDa) | GOX and HRP were spatially confined in the shell and core of microcapsules and achieved efficient enzyme cascade reaction | 117 |
| (7) Multicompartmental proteinosomes | GOX + insulin | Polyethylene oxide (PEO) (300 kDa) + DEX (70 kDa) | Achieving pH self-monitoring and spatiotemporal regulation of insulin release | 118 |
| (8) Multi-aqueous core hydrogel capsules | Heterogeneous cells | PEG (20 kDa) + DEX (500 kDa) | Possessing two independent aqueous phase chambers | 119 |