Figure 6.

Synaptic and immune suppressive actions mediated by cannabinoid receptors in neurons and glial cells. The activation of CB₁R reduces Ca²⁺ release from presynaptic neurons by inhibiting VGSCs at the presynaptic membrane, resulting in decreased Ca²⁺ influx in postsynaptic neurons. CB₁R activation localized on astrocytes induces Ca²⁺ release by the Gαq pathway. The activation of CB₂R localized on microglia reduces cytokine release, indicating its role in immune suppression.