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Cryo-EM structure of the human A1R-Gαi2 protein complex bound to adenosine (Endogenous agonist) and MIPS521 (PAM) (PDB ID: 7LD3). The black squares showed the orthosteric binding site of adenosine in the central of TMD (left). Adenosine is shown as blue sticks. Residues interacting with adenosine are shown as purple sticks. The black squares showed the allosteric binding site of MIPS521 in the intersection of the TMD and lipid interface (right).
