Table 3.
Clinical trials of a GB-related product for acute ischemic cerebrovascular disease.
| Registration No. | Recruitment status | Study title | Target disease | Phase | Interventions |
|---|---|---|---|---|---|
| CTR20200390 | Completed | A phase I clinical trial to evaluate the safety and tolerability of single and multiple intravenous ginkgolide B injections in healthy Chinese subjects | Acute ischemic stroke | Ⅰ | Ginkgolide B injection |
| CTR20200487 | Recruiting | A phase I clinical study to evaluate the safety, tolerability, and pharmacokinetics of ginkgolide B injection in healthy Chinese volunteers | Acute ischemic stroke | Ⅰ | Ginkgolide B injection |
| ChiCTR-IPR-17012310 | Recruiting | Ginkgolide in ischemic stroke patients with large artery atherosclerosis (GISAA)193 | Stroke | IV | Ginkgolide injection + oral aspirin |
| NCT03772847 | Completed | Ginkgolide with intravenous alteplase thrombolysis in acute ischemic stroke neurological improving trial200 | Intravenous alteplase thrombolysis Neurological improving |
IV | Ginkgolide plus alteplase |
| ChiCTR-ONC–13003247 | Completed | A multicenter clinical trial assessment of Baiyu Ginkgolide injection, in the treatment of ischemic stroke with blood stasis syndrome | Ischemic stroke | IV | Baiyu Ginkgolide injection |
| NCT01958957 | Completed | A safety study of ginkgolides meglumine injection in the treatment of ischemic stroke | Ischemic stroke | IV | Ginkgolides Meglumine Injection |
| CTR20160610 | Completed | Single and multiple administration of dimethylaminoethyl ginkgolide B mesylate tablets in a randomized double-blind placebo-controlled PK/PD study and the effect of eating on PK/PD | Acute ischemic cerebrovascular disease | Ⅰ | Dimethylaminoethyl ginkgolide B mesylate tablets |
| CTR20140805 | Completed | Research protocol of multiple administration, dose-escalation, randomized, double-blind, placebo-controlled phase I clinical trial of dimethylaminoethyl ginkgolide B mesylate injection | Acute ischemic stroke | Ⅰ | Dimethylaminoethyl ginkgolide B mesylate injection |
| CTR20210113 | Recruiting | A phase I clinical study on the safety, tolerability and pharmacokinetics/pharmacodynamics (PK/PD) of a single dose of dimethylaminoethyl ginkgolide B mesylate injection in healthy adult subjects. | Acute ischemic cerebrovascular disease | Ⅰ | Dimethylaminoethyl ginkgolide B mesylate injection |
| CTR20210115 | Recruiting | Phase I clinical study of safety, tolerability, and pharmacokinetics/pharmacodynamics (PK/PD) of multidose dimethylaminoethyl ginkgolide B mesylate tablets in healthy adult subjects. | Acute ischemic cerebrovascular disease | Ⅰ | Dimethylaminoethyl ginkgolide B mesylate tablets |