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(A) The structure of eupenifeldin. (B, C) Eupenifeldin is cytotoxic in high-grade serous ovarian cancer cell lines at 72 h. Black line indicates paclitaxel control, and gray line indicates eupenifeldin treatment. (D) OVCAR5 and (E) OVCAR8 HGSOC cells have significantly decreased wound closure when treated with eupenifeldin. All data are mean ± SEM from three biological replicates, and statistical analysis was conducted via one-way ANOVA with Dunnett’s multiple comparison. *P < 0.05.
