Table 1.

Chemoprevention strategies

Strategy	Description
SMC	The administration of a full treatment of antimalarial medicine during the malaria season to prevent illness. Historically, SMC has been administered to children 3 to 59 months of age in areas with highly seasonal malaria transmission, with SP+AQ given monthly during the transmission season for a maximum of four monthly doses. The current WHO recommendation does not specify strict ages, transmission intensity thresholds, number of cycles, or specific drugs.3
IPTi/PMC	Previous WHO recommendations for IPTi included three doses of SP at 2, 3, and 9 months of age concomitantly with vaccinations given through the EPI in areas where SP resistance was not high. The 2023 WHO recommendation for PMC removes the specifications on number of doses and targeted ages for these doses, and expands the eligible age group beyond 1 year where severe disease burden is high.
IPTsc	In settings with moderate to high perennial or seasonal malaria transmission, the WHO recommends that school-aged children (5 to 15 years of age) receive antimalarials at regular intervals, facilitated through schools.

EPI = Expanded Program on Immunization; IPTi = intermittent preventive treatment during infancy; IPTsc = intermittent preventive treatment in school-aged children; PMC = perennial malaria chemoprevention; SMC = seasonal malaria chemoprevention; SP+AQ = sulfadoxine-pyrimethamine plus amodiaquine.