Table 2.
Simple and multiple logistic regression analysis to determine factors associated with ICU mortality among patients admitted to ICU with sepsis
| Variables | Crude OR | 95% CI | P-value | Adjusted OR | 95% CI | P-value |
|---|---|---|---|---|---|---|
| Demography | ||||||
| Age (years old) | 1.01 | 1.00, 1.03 | 0.143 | |||
| Gender (male) | 1.19 | 0.68, 2.08 | 0.542 | |||
| Admission characteristics | ||||||
| Location | ||||||
| General ICU | ref | |||||
| SICU | 0.78 | 0.39, 1.54 | 0.472 | |||
| TICU | 0.38 | 0.12, 1.19 | 0.098 | |||
| Neuro ICU | 0.35 | 0.11, 1.09 | 0.069 | |||
| 8S (high dependency ward) | 0.72 | 0.35, 1.48 | 0.372 | |||
| CCU | 1.41 | 0.23, 8.77 | 0.716 | |||
| Type of admission | ||||||
| Medical | ref | |||||
| Elective surgical | 0.45 | 0.05, 3.93 | 0.469 | |||
| Emergency surgical | 0.51 | 0.27, 0.94 | 0.032 | |||
| Comorbidities | ||||||
| Cardiovascular disease | 1.32 | 0.77, 2.26 | 0.315 | |||
| Chronic lung disease | 0.87 | 0.40, 1.87 | 0.717 | |||
| Chronic neurological disease | 2.26 | 0.59, 8.64 | 0.234 | |||
| Chronic kidney disease | 2.11 | 1.22, 3.65 | 0.007 | |||
| Chronic liver disease | 8.52 | 0.87, 83.17 | 0.065 | |||
| Peptic ulcer disease | 2.79 | 0.39, 20.15 | 0.309 | |||
| Diabetes | 1.72 | 1.02, 2.93 | 0.044 | |||
| Connective tissue disease | 0.77 | 0.25, 2.42 | 0.657 | |||
| Malignancy | 0.50 | 0.16, 1.50 | 0.214 | |||
| Clinical characteristics | ||||||
| Mean arterial pressure, mmHg | 0.99 | 0.97, 1.01 | 0.093 | |||
| Systolic blood pressure, mmHg | 0.99 | 0.98, 1.01 | 0.083 | |||
| Heart rate, beats/min | 1.00 | 0.99, 1.02 | 0.607 | |||
| Temperature (°C) | 1.18 | 0.93, 1.50 | 0.177 | |||
| Respiratory rate (breaths/min) | 0.98 | 0.93, 1.04 | 0.606 | |||
| GCS | 0.83 | 0.77, 0.89 | < 0.001 | 0.90 | 0.82, 0.98 | 0.019 |
| SOFA score | 1.29 | 1.18, 1.41 | < 0.001 | 1.22 | 1.11, 1.35 | < 0.001 |
| Haematological and biochemical parameters | ||||||
| Total WBC (×109) | 1.00 | 0.99, 1.02 | 0.706 | |||
| Haemoglobin (g/dL) | 0.91 | 0.81, 1.03 | 0.132 | |||
| Haematocrit | 1.00 | 0.99, 1.01 | 0.982 | |||
| Platelet (×103) | 1.00 | 0.99, 1.01 | 0.593 | |||
| Creatinine (μmol/L) | 1.01 | 1.01, 1.02 | 0.005 | |||
| Sodium (mEq/L) | 1.00 | 0.97, 1.02 | 0.865 | |||
| Albumin (g/dL) | 0.93 | 0.90, 0.97 | <0.001 | |||
| Aspartate aminotransferase (unit/L) | 1.00 | 0.99, 1.01 | 0.060 | |||
| Alanine aminotransferase (unit/L) | 1.00 | 1.00, 1.01 | 0.018 | |||
| Total bilirubin (μmol/L) | 1.02 | 1.01, 1.03 | 0.011 | |||
| Urea (mmol/L) | 1.01 | 0.99, 1.03 | 0.370 | |||
| pH | 0.03 | 0.01, 0.45 | 0.011 | |||
| PaO2 | 1.00 | 0.99, 1.01 | 0.629 | |||
| FiO2 | 8.78 | 2.39, 32.2 | 0.001 | |||
| PF ratio | 1.01 | 1.00, 1.02 | 0.002 | |||
| Treatment in ICU | ||||||
| Mechanical ventilation | 3.92 | 1.16, 13.25 | 0.028 | |||
| Renal replacement therapy | 4.48 | 2.58, 7.76 | 0.000 | |||
| Ionotropic or vasopressor | 4.25 | 1.62, 11.11 | 0.003 | |||
Notes:
*
Automated likelihood-ratio-test-based backward selection method applied for multiple logistic regression analysis; Area under ROC curve = 75.5% (95% CI: 69.6, 81.4); No multicollinearity and no interaction between variables; Hosmer-Lemeshow test P-value = 0.714,
OR = odds ratio