The in vitro therapeutic and mean therapeutic index values for DFO, Dp44mT, DpC, Dp4e4mT, and the Dp4e4mT complexes using the neoplastic SK-N-MC and AsPC-1 cell-types relative to mortal MRC-5 fibroblasts after a 72 h/37 °C incubation. Results are from mean IC50 values from 3 experiments in each cell-type.
| Compounds | Therapeutic index | Mean therapeutic index | |
|---|---|---|---|
| SK-N-MC | AsPC-1 | ||
| DFO | 3 | 9 | 6 |
| Dp44mT | 152 | 71 | 112 |
| DpC | 149 | 165 | 157 |
| Dp4e4mT | 301 | 120 | 210 |
| [Fe(Dp4e4mT)2]+ | 9 | 9 | 9 |
| [Co(Dp4e4mT)2]+ | 4 | 2 | 3 |
| [Ni(Dp4e4mT)2] | 250 | 62 | 156 |
| [Cu(Dp4e4mT)Cl] | 130 | 130 | 130 |
| [Cu(Dp4e4mT)2] | 85 | 113 | 99 |
| [Zn(Dp4e4mT)2] | 187 | 125 | 156 |
| [Ga(Dp4e4mT)2]+ | 192 | 154 | 173 |
| [Pd(Dp4e4mT)Cl] | 3 | 3 | 3 |