TABLE 3.
Alterations in Th1 EMSA patterns and TCRζ expression in LL patients
| Group | Mean level of:
|
No. of patients with decreased TCRζ expression/no. testedb | No. of patients with loss of Th1/no. tested | |
|---|---|---|---|---|
| IL-10a (pg/ml) | IFN-γ (U/ml) | |||
| Normal controls | 180 | 43.00 | 0/5 | 0/5 |
| LL patients | ||||
| Low IL-10 | 222 | 32.96 | 8/15 | 3/7 |
| High IL-10 | 731 | 26.44 | 7/8 | 6/7 |
a
P = 0.0001 for high-IL-10 versus low-IL-10 patients. P = 0.0039 for healthy controls versus high-IL-10 patients. P = 0.6297 for healthy controls versus low-IL-10 patients.
b
Decreased TCRζ expression was defined as values ≤55% of those for healthy controls, as measured by densitometry.