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[Preprint]. 2024 Dec 1:2023.12.27.573461. Originally published 2023 Dec 28. [Version 2] doi: 10.1101/2023.12.27.573461

Figure 5. hDel_2247 regulates PLPP1 and drives lacZ expression in developing anterior cortex and olfactory bulb.

Figure 5.

a, hDel_2247-targeting sgRNA log2 fold-change (hDel-v1) and Omni ATAC-seq, H3K4me1, H3K4me3, and H3K27ac in C3624K.

b, Differential PLPP1 expression for cells (‘pseudobulk’) harboring the indicated hDel_2247-targeting sgRNA (*FDR < 0.1).

c, Representative E13.5 hDel_2247::lacZ mouse embryo stained for β-galactosidase (LacZ) activity.

d, Sagittal section showing lacZ expression in olfactory bulb and anterior cortex. Ctx: cortex. OB: olfactory bulb. SE: septum. P: posterior. A: anterior.