Figure 4:

Identification of key driver genes (KDGs). (A) Within the Mergeomics framework [68], RA signature genes are leveraged to test the significance of each gene node within a given network. We performed the analysis with 2 different RA signature gene sets (DEG list and Literature list) and 10 networks. (B) Number of obtained KDGs for each tested network using the DEG and Literature lists. While the overlap between the RA signature gene sets is small, we observe a high overlap (in red) between the KDGs inferred from both lists across different cell types. KDGs for all networks are provided in Supplementary Data 2). DC:dendritic cells; LN: lymph node; PPI: Protein-Protein interaction network.