Table 2:
Top 10 ranked TF regulators in each synovial cell type, along with their Z-scores in parentheses. TFs found in the top 10 in more than one network are highlighted in bold. Z-statistics for all TFs in each network are available in Supplementary Data 1).
| Rank | Syn. Tissue | Syn. Monocyte | Syn. Fibroblast (FLS) | Syn. B cell | Syn. T cell |
|---|---|---|---|---|---|
| 1 | ZNF282 (7.01) | NFE2 (5.71) | RORC (3.39) | JUN (6.59) | HAND1 (5.85) |
| 2 | SCRT2 (6.30) | CEBPZ (5.63) | NKX2–1 (3.37) | STAT5B (4.89) | REST (4.97) |
| 3 | NR6A1 (4.06) | IRF8 (5.59) | HOXA1 (3.20) | CTCF (4.04) | ELF4 (4.59) |
| 4 | SCRT1 (3.70) | PBX3 (5.60) | ETV2 (2.67) | TCF3 (3.45) | EHF (4.21) |
| 5 | FOSL2 (3.11) | NFYA (5.49) | MITF (2.64) | JUND (3.37) | NR4A1 (3.36) |
| 6 | RFX5 (2.52) | RFX5 (4.62) | SIX5 (2.61) | NKX2–3 (3.20) | SCRT1 (3.32) |
| 7 | MXI1 (2.41) | IRF9 (3.97) | ELF5 (2.46) | KLF13 (3.03) | NRF1 (3.19) |
| 8 | ZBTB33 (2.29) | MXI1 (3.32) | ZBTB1 (2.42) | PBX3 (2.69) | EPAS1 (2.94) |
| 9 | JUNB (2.07) | IRF4 (3.21) | FOXC2 (2.27) | TWIST1 (2.69) | NFYB (2.81) |
| 10 | RELA (2.05) | ARID2 (2.88) | TBX4 (2.23) | FOSB (2.52) | CEBPZ (2.77) |