Table 5:

Key transcription factors (TFs) implicated in the regulation of RA identified in our analyses (Z-statistics > 1), ordered from highest to lowest Z-statistics for the different cell types. TFs identified in more than one cell type are highlighted in bold.

Cell type	( # of TFs)	List of TF drivers (Ranked from highest to lowest Z-statistics)
Syn. Tissue	(10)	FOSL2, RFX5, RELA, JUNB, FOS, MYBL1, NFKB2, ZNF274, HIVEP1, HIVEP2
Syn. Monocyte	(11)	IRF8, RFX5, IRF9, IRF2, CREB5, IRF3, XBP1, STAT2, EOMES, BCL11A, SPI1
Syn. Fibroblast	(18)	MITF, CBFB, IKZF1, HLX, BACH1, FOS, ETV7, RFX5, HIF1A, TGIF1, ELF4, RUNX1, NFATC1, IRF7, CREM, FOSL1, FLI1, ELF1
Syn. B cell	(19)	STAT5B, JUND, KLF13, FOSB, FOSL1, KLF2, PLAGL1, EGR3, CEBPD, TCF7, RELB, HBP1, RUNX3, BATF3, RORA, STAT6, EGR2, BHLHE40, CIC
Syn. T cell	(15)	ELF4, NR4A1, ETV6, MITF, ETS2, ETV7, MSC, FOSB, RELA, RFX5, KLF2, REL, ATF4, HIVEP1, VENTX, IRF9