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[Preprint]. 2023 Dec 28:2023.12.28.573261. [Version 1] doi: 10.1101/2023.12.28.573261

Table 10.

Optimization of compounds based on QSAR.

graphic file with name nihpp-2023.12.28.573261v1-t0038.jpg
Name R X1 X2 TLK2 IC50 (nM) FLT3(%) TRKC (%) TLK1(%)
128 Me N C-H 18 24 35 84
129 H C-H N 2600 87 86 92
a.

8-point dose response (n=1);

b.

percentage inhibition at 0.5 μM (n=2)