Table 11.
Compound results based on QSAR prediction.
| Compound | TLK2 Inhibition Activity (nM) | |||
|---|---|---|---|---|
| Predicted | Found | Log Predicted | log Actual | |
| 117 | 51 | 23 | 7.29 | 7.64 |
| 118 | 56 | 36 | 7.25 | 7.44 |
| 119 | 50 | 77 | 7.30 | 7.11 |
| 120 | 370 | 27 | 6.44 | 7.57 |
| 121 | 68 | 180 | 7.17 | 6.74 |
| 122 | 180 | 47 | 6.75 | 7.33 |
| 123 | 1800 | 630 | 5.76 | 6.20 |
| 124 | 40 | 260 | 7.40 | 6.59 |
| 125 | 8 | 120 | 8.08 | 6.92 |
| 126 | 8 | 15 | 8.12 | 7.82 |
| 127 | 37 | 46 | 7.44 | 7.34 |
| 128 | 180 | 18 | 6.74 | 7.74 |
| 129 | 960 | 2600 | 6.02 | 5.59 |