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[Preprint]. 2023 Dec 28:2023.12.28.573261. [Version 1] doi: 10.1101/2023.12.28.573261

Table 3.

Investigation of sulphonamide and ether derivatives.

graphic file with name nihpp-2023.12.28.573261v1-t0019.jpg
Name R1 X1 X2 TLK2 IC50(nM)a FLT3 (%)b TRKC (%)b
52 graphic file with name nihpp-2023.12.28.573261v1-t0020.jpg C-H C-H > 20000 31 1.6
53 N C-H > 20000 55 12
54 graphic file with name nihpp-2023.12.28.573261v1-t0021.jpg C-H C-H > 20000 27 3.0
55 N C-H > 20000 62 27
57 graphic file with name nihpp-2023.12.28.573261v1-t0022.jpg C-H C-H 560 8.3 2.8
58 N C-H 1600 33 11
59 C-H N 160 25 5.9
a.

8-point dose response (n=1);

b.

percentage inhibition at 0.5 μM (n=2)