Table 4.

Initial investigation of amide derivatives.

Name	R1	X1	X2	TLK2IC50(nM)a	FLT3 (%)b	TRKC (%)b
65		C-H	C-H	170	11	4.9
66		C-H	C-H	2400	25	2.3
67		N	C-H	2300	61	6.0
68		C-H	N	2500	75	15
69		C-H	C-H	150	28	11
70		N	C-H	100	46	16
71		C-H	N	130	58	32
72		C-H	C-H	820	21	19
73		N	C-H	34	44	30
74		C-H	N	110	48	33
75		C-H	C-H	120	30	28
76		C-H	N	130	42	33

^a.8-point dose response (n=1);

^b.percentage inhibition at 0.5 μM (n=2)