Table 5.

Significant structural variants from association analysis (P < 5 × 10⁻⁸).

Name	N	AF	beta	P	AF (case)	AF (control)	Odds Ratio	Fisher’s P	Gene
chr17:46009357–46009595:DEL*	4357	0.16	−1.22	3.14×10−50	0.054	0.23	0.19	5.80×10−118	MAPT
chr17:46146541–46146855:DEL*	3697	0.19	−1.12	2.13×10−39	0.079	0.25	0.26	1.58×10−83	KANSL1
chr17:46099028–46099351:DEL*	3699	0.22	−1.07	3.88×10−37	0.11	0.28	0.33	2.05×10−66	KANSL1
chr14:105864208–105916743:DEL	4378	0.010	−1.53	4.74×10−14	0.0053	0.014	0.39	1.33×10−04	IGH
chr6:149762615–149763234:DEL	3811	0.55	0.50	8.60×10−12	0.75	0.42	4.19	6.00×10−182	PCMT1
chr19:41102802–41104285:DEL	2921	0.17	0.64	7.46×10−09	0.21	0.14	1.59	5.95×10−11	CYP2A13
chr1:152880979–152880979:INS	2872	0.74	0.67	2.37×10−08	0.79	0.71	1.62	1.46×10−13	SMCP

^*Represents SVs with DNA samples available and PCR validated