Table 1.
Summary of statistical analysis results of white matter volume. Significance codes:.: < 0.1 *P < 0.05, **P < 0.01, ***P < 0.001.
| WM Volume | s(Age_norm):Early High | s(Age_norm):Late-Low | R-sq.(adj) | Intercept | TNE_Group | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ROI | edf | Ref.df | F | P -value | edf | Ref.df | F | P -value | Estimate | Std. Error | t value | Pr(>|t|) | Estimate | Std. Error | t value | Pr(>|t|) | Corrrected p | ||
| Whole Brain | 1 | 1 | 91.75 | <2e − 16*** | 1.454 | 1.454 | 107.89 | <2e − 16*** | 0.409 | 26103.1 | 645.5 | 40.437 | <2e − 16*** | −1064.3 | 913.9 | −1.165 | 0.247 | NA | |
| Cerebellum | 1 | 1 | 1.934 | 0.167795 | 1.514 | 1.514 | 9.384 | 0.000565*** | 0.102 | 2749.765 | 97.006 | 28.346 | <2e − 16*** | 4.627 | 137.547 | 0.034 | 0.973 | 12.649 | |
| Cingulate | 1 | 1 | 21.43 | 1.26e − 05*** | 1 | 1 | 8.733 | 0.00399** | 0.236 | 392.61 | 16.45 | 23.87 | <2e − 16*** | −49.41 | 23.31 | −2.12 | 0.0368 | * | 0.4784 |
| Corpus Callosum | 1 | 1 | 50.48 | <2e − 16*** | 3.809 | 3.809 | 25.85 | <2e − 16*** | 0.188 | 840.14 | 34.11 | 24.633 | <2e − 16*** | −10.65 | 48.28 | −0.221 | 0.826 | 10.738 | |
| Frontal | 1 | 1 | 71.18 | <2e − 16*** | 1 | 1 | 50.7 | <2e − 16*** | 0.425 | 3924.9 | 130.1 | 30.169 | <2e − 16*** | −520.9 | 184.4 | −2.825 | 0.00582 | * * | 0.07566 |
| Insula | 2.3 | 2.3 | 2.953 | 0.0865 . | 2.224 | 2.224 | 6.763 | 0.0015** | 0.1 | 46.357 | 3.047 | 15.214 | <2e − 16*** | 1.298 | 4.314 | 0.301 | 0.764 | 9.932 | |
| Occipital | 1.196 | 1.196 | 2.463 | 0.0880 . | 1 | 1 | 8.446 | 0.0046** | 0.051 | 4205.2 | 109.3 | 38.471 | <2e − 16*** | −118.8 | 154.9 | −0.767 | 0.445 | 5.785 | |
| Parietal | 1 | 1 | 40.54 | <2e − 16*** | 1 | 1 | 33.29 | <2e − 16*** | 0.278 | 4247.1 | 129.9 | 32.69 | <2e − 16*** | −314.8 | 184.1 | −1.71 | 0.0907 | . | 1.1791 |
| Pons and Medulla | 5.675 | 5.675 | 56.58 | <2e − 16*** | 3.22 | 3.22 | 92.73 | <2e − 16*** | 0.674 | 1264.76 | 35.12 | 36.013 | <2e − 16*** | 38.78 | 49.26 | 0.787 | 0.433 | 5.629 | |
| Prefrontal | 1 | 1 | 72.9 | <2e − 16*** | 1 | 1 | 32.19 | 3.02e − 07*** | 0.447 | 1993.91 | 69.02 | 28.888 | <2e − 16*** | −340.17 | 97.85 | −3.476 | 0.000784 | * * * | 0.010192 |
| Subcortical | 1.593 | 1.593 | 6.68 | 0.00273** | 2.709 | 2.709 | 30.64 | <2e − 16*** | 0.303 | 2416.6 | 101.3 | 23.862 | <2e − 16*** | 244.6 | 143.4 | 1.706 | 0.0916 | . | 1.1908 |
| Temporal Audigory | 3.754 | 3.754 | 13.58 | <2e − 16*** | 3.093 | 3.093 | 79.43 | <2e − 16*** | 0.368 | 747.83 | 33.1 | 22.592 | <2e − 16*** | 61.46 | 46.8 | 1.313 | 0.193 | 2.509 | |
| Temporal Limbic | 1.921 | 1.921 | 12.53 | 1.77e − 05*** | 1.562 | 1.562 | 35.02 | <2e − 16*** | 0.206 | 464.71 | 23.25 | 19.985 | <2e − 16*** | 5.67 | 32.9 | 0.172 | 0.864 | 11.232 | |
| Temporal Visual | 2.162 | 2.162 | 9.51 | 0.000128*** | 1 | 1 | 94.74 | <2e − 16*** | 0.23 | 2765.427 | 85.319 | 32.41 | <2e − 16*** | −7.225 | 120.695 | −0.06 | 0.952 | 12.376 | |