Table 2.
Summary of statistical analysis results of white matter integrity. Significance codes:.: < 0.1 *P < 0.05, **P < 0.01, ***P < 0.001.
FA | s(Age_norm):Early-High | s(Age_norm):Late-Low | R-sq.(adj) | Intercept | TNE_Group | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ROI | edf | Ref.df | F | P -value | edf | Ref.df | F | P -value | Estimate | Std. Error | t value | Pr(>|t|) | Estimate | Std. Error | t value | Pr(>|t|) | Corrected p | ||
Whole Brain | 1.813 | 1.813 | 7.698 | 0.000824*** | 3.032 | 3.032 | 26.628 | <2e-16*** | 0.391 | 0.379301 | 0.003771 | 100.572 | <2e-16*** | 0.009637 | 0.005345 | 1.803 | 0.0748 | . | NA |
Cerebellum | 1.349 | 1.349 | 0.599 | 0.635907 | 2.687 | 2.687 | 6.908 | 0.000687*** | 0.204 | 0.378917 | 0.004269 | 88.759 | < 2e-16*** | 0.016125 | 0.006053 | 2.664 | 0.00918 | * * | 0.11934 |
Cingulate | 1.922 | 1.922 | 20.8 | 1.34e-07*** | 2.274 | 2.274 | 20.68 | < 2e-16*** | 0.357 | 0.358988 | 0.005104 | 70.328 | <2e-16*** | −0.00614 | 0.007231 | −0.849 | 0.398 | 5.174 | |
Corpus Callosum | 1.786 | 1.786 | 2.407 | 0.0604 . | 2.396 | 2.396 | 13.268 | 3.17e-06*** | 0.186 | 0.459242 | 0.006547 | 70.147 | <2e-16*** | 0.004986 | 0.009272 | 0.538 | 0.592 | 7.696 | |
Frontal | 2.351 | 2.351 | 4.148 | 0.0185* | 2.812 | 2.812 | 12.764 | 1.48e-06*** | 0.253 | 0.394061 | 0.003953 | 99.685 | <2e-16*** | 0.009415 | 0.005598 | 1.682 | 0.0962 | . | 1.2506 |
Insula | 2.241 | 2.241 | 8.912 | 0.000321*** | 2.525 | 2.525 | 14.418 | 1.1e-06*** | 0.324 | 0.269295 | 0.002878 | 93.557 | <2e-16*** | 0.007537 | 0.004077 | 1.849 | 0.0679 | . | 0.8827 |
Occipital | 1.969 | 1.969 | 16.08 | 1.22e-06*** | 3.276 | 3.276 | 39.45 | <2e-16*** | 0.527 | 0.3864 | 0.003887 | 99.408 | <2e-16*** | 0.007903 | 0.005512 | 1.434 | 0.155 | 2.015 | |
Parietal | 2.328 | 2.328 | 11.12 | 3.66e-05*** | 3.022 | 3.022 | 34.65 | <2e-16*** | 0.391 | 0.378698 | 0.004293 | 88.219 | <2e-16*** | 0.005923 | 0.006079 | 0.974 | 0.333 | 4.329 | |
Pons and Medulla | 1 | 1 | 13.57 | 0.000396*** | 3.125 | 3.125 | 23.82 | <2e-16*** | 0.4 | 0.378703 | 0.004715 | 80.317 | <2e-16*** | 0.01753 | 0.006686 | 2.622 | 0.0103 | * | 0.1339 |
Prefrontal | 1 | 1 | 10.8 | 0.00146** | 2.508 | 2.508 | 16.91 | 1.56e-07*** | 0.258 | 0.3549 | 0.004459 | 79.592 | <2e-16*** | 0.009183 | 0.006319 | 1.453 | 0.15 | 1.95 | |
Subcortical | 1 | 1 | 19.18 | 3.31e-05*** | 2.972 | 2.972 | 23.82 | <2e-16*** | 0.369 | 0.357371 | 0.003898 | 91.686 | <2e-16*** | 0.010287 | 0.005527 | 1.861 | 0.0661 | . | 0.8593 |
Temporal Audigory | 2.262 | 2.262 | 17 | 5.33e-07*** | 2.874 | 2.874 | 30.72 | <2e-16*** | 0.416 | 0.366904 | 0.004437 | 82.696 | <2e-16*** | 0.01196 | 0.006283 | 1.904 | 0.0603 | . | 0.7839 |
Temporal Limbic | 1.553 | 1.553 | 0.245 | 0.63332 | 2.62 | 2.62 | 4.148 | 0.00754** | 0.125 | 0.360314 | 0.004483 | 80.378 | <2e-16*** | 0.012675 | 0.006352 | 1.995 | 0.0491 | * | 0.6383 |
Temporal Visual | 1.535 | 1.535 | 3.386 | 0.0299* | 3.081 | 3.081 | 20.419 | <2e-16*** | 0.317 | 0.401309 | 0.003616 | 110.983 | <2e-16*** | 0.007141 | 0.005128 | 1.392 | 0.167 | 2.171 | |
MD | s(Age_norm):Early-High | s(Age_norm):Late-Low | R-sq.(adj) | Intercept | TNE_Group | ||||||||||||||
ROI | edf | Ref.df | F | P -value | edf | Ref.df | F | P-value | Estimate | Std. Error | t value | Pr(>|t|) | Estimate | Std. Error | t value | Pr(>|t|) | |||
Whole Brain | 2.216 | 2.216 | 4.97 | 0.00826** | 3.077 | 3.077 | 5.635 | 0.00127** | 0.398 | 7.44E-04 | 6.68E-06 | 111.526 | < 2e-16*** | −5.05E-05 | 9.46E-06 | −5.335 | 7.52E-07 | * * * | NA |
Cerebellum | 2.205 | 2.205 | 13.151 | 6.86e-06*** | 2.927 | 2.927 | 6.031 | 0.00129** | 0.426 | 6.72E-04 | 7.44E-06 | 90.28 | < 2e-16*** | −5.95E-05 | 1.05E-05 | −5.64 | 2.08E-07 | * * * | 2.70E-06 |
Cingulate | 2.125 | 2.125 | 1.824 | 0.188 | 2.961 | 2.961 | 8.84 | 4.64e-05*** | 0.349 | 7.80E-04 | 7.79E-06 | 100.175 | < 2e-16*** | −4.48E-05 | 1.10E-05 | −4.055 | 0.000109 | * * * | 1.42E-03 |
Corpus Callosum | 1.951 | 1.951 | 1.866 | 0.21046 | 2.562 | 2.562 | 4.519 | 0.00926** | 0.271 | 7.87E-04 | 6.13E-06 | 128.406 | < 2e-16*** | −3.33E-05 | 8.68E-06 | −3.837 | 0.000235 | * * * | 3.06E-03 |
Frontal | 2.54 | 2.54 | 1.695 | 0.221197 | 3.216 | 3.216 | 7.127 | 0.000176*** | 0.35 | 7.30E-04 | 7.26E-06 | 100.595 | < 2e-16*** | −4.54E-05 | 1.03E-05 | −4.415 | 2.91E-05 | * * * | 3.78E-04 |
Insula | 1 | 1 | 23.63 | 5.29e-06*** | 2.635 | 2.635 | 3.086 | 0.0292* | 0.384 | 7.82E-04 | 7.76E-06 | 100.766 | < 2e-16*** | −5.72E-05 | 1.10E-05 | −5.193 | 1.31E-06 | * * * | 1.70E-05 |
Occipital | 1.194 | 1.194 | 12.352 | 0.000654*** | 2.838 | 2.838 | 4.944 | 0.004488** | 0.388 | 7.25E-04 | 6.67E-06 | 108.694 | < 2e-16*** | −5.14E-05 | 9.47E-06 | −5.428 | 4.99E-07 | * * * | 6.49E-06 |
Parietal | 2.165 | 2.165 | 4.312 | 0.01553* | 2.928 | 2.928 | 5.801 | 0.00148** | 0.361 | 7.41E-04 | 7.52E-06 | 98.562 | < 2e-16*** | −5.11E-05 | 1.07E-05 | −4.796 | 6.64E-06 | * * * | 8.63E-05 |
Pons and Medulla | 1 | 1 | 20.497 | 1.89e-05*** | 3.159 | 3.159 | 6.223 | 0.000576*** | 0.404 | 7.47E-04 | 7.31E-06 | 102.163 | < 2e-16*** | −5.42E-05 | 1.04E-05 | −5.217 | 1.20E-06 | * * * | 1.56E-05 |
Prefrontal | 3.109 | 3.109 | 1.652 | 0.142 | 3.149 | 3.149 | 8.229 | 5.34e-05*** | 0.417 | 7.62E-04 | 7.21E-06 | 105.739 | < 2e-16*** | −5.07E-05 | 1.02E-05 | −4.966 | 3.44E-06 | * * * | 4.47E-05 |
Subcortical | 2.027 | 2.027 | 6.646 | 0.00207** | 2.896 | 2.896 | 4.945 | 0.00415** | 0.398 | 7.54E-04 | 6.49E-06 | 116.129 | < 2e-16*** | −5.04E-05 | 9.21E-06 | −5.472 | 4.22E-07 | * * * | 5.49E-06 |
Temporal Audigory | 1.717 | 1.717 | 12.814 | 0.00028*** | 2.771 | 2.771 | 3.654 | 0.01668* | 0.402 | 7.70E-04 | 7.33E-06 | 105.034 | < 2e-16*** | −5.65E-05 | 1.04E-05 | −5.434 | 4.90E-07 | * * * | 6.37E-06 |
Temporal Limbic | 1 | 1 | 19.169 | 3.3e-05*** | 2.46 | 2.46 | 5.067 | 0.00468** | 0.451 | 7.98E-04 | 6.50E-06 | 122.735 | < 2e-16*** | −5.64E-05 | 9.22E-06 | −6.113 | 2.57E-08 | * * * | 3.34E-07 |
Temporal Visual | 1.876 | 1.876 | 9.233 | 0.00125** | 2.968 | 2.968 | 5.044 | 0.00317** | 0.378 | 7.46E-04 | 6.85E-06 | 108.96 | < 2e-16*** | −5.00E-05 | 9.71E-06 | −5.152 | 1.59E-06 | * * * | 2.07E-05 |