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. 2023 Dec 18;34(1):bhad472. doi: 10.1093/cercor/bhad472

Table 1.

Demographic info, lifestyle factors, and PRSs of the UKB subjects used in the association study on DTI phenotype.

APOE-ε4 homozygote APOE-ε3 homozygote APOE-ε2 homozygote APOE-ε4/
APOE-ε3
APOE-ε2/
APOE-ε3
APOE-ε4/
APOE-ε2
Total
Characteristicsa (n = 770) (n = 20,770) (n = 202) (n = 8130) (n = 4330) (n = 833) (n = 35,035)
Age at baseline, mean(sd)/median(range)
54.2 (7.26) 54.9 (7.46) 54.7 (7.67) 54.5 (7.38) 55.0 (7.41) 54.8 (7.55) 54.8 (7.44)
55.0 [40.0, 69.0] 55.0 [40.0, 70.0] 55.0 [40.0, 69.0] 55.0 [40.0, 70.0] 56.0 [40.0, 70.0] 55.0 [40.0, 70.0] 55.0 [40.0, 70.0]
Age at brain imaging, mean(sd)/median(range)
63.1 (7.30) 63.8 (7.55) 63.7 (7.88) 63.3 (7.47) 63.8 (7.50) 63.7 (7.63) 63.6 (7.53)
64.0 [47.0, 80.0] 64.0 [45.0, 81.0] 64.0 [46.0, 80.0] 64.0 [46.0, 81.0] 64.0 [45.0, 81.0] 64.0 [47.0, 80.0] 64.0 [45.0, 81.0]
Ethnicity, number (%)
 British 725 (94.16) 19,082 (91.87) 187 (92.57) 7535 (92.68) 4002 (92.42) 789 (94.72) 32,320 (92.25)
 Others 45 (5.84) 1688 (8.13) 15 (7.43) 595 (7.32) 328 (7.58) 44 (5.28) 2715 (7.75)
Sex, number (%)
 Male 420 (54.55) 9929 (47.8) 93 (46.04) 3737 (45.97) 2032 (46.93) 374 (44.9) 16,515 (47.14)
 Female 350 (45.45) 10,841 (52.2) 109 (53.96) 4393 (54.03) 2298 (53.07) 459 (55.1) 18,520 (52.86)
Disease status, number (%)
 Dementia 0 (0) 1 (0) 1 (0.5) 2 (0.02) 2 (0.05) 0 (0) 6 (0.02)
 Not dementia 770 (100) 20,769 (100) 201 (99.5) 8128 (99.98) 4328 (99.95) 833 (100) 35,029 (99.98)
Family illness, number (%)
 Father has AD 128 (16.62) 1764 (8.49) 19 (9.41) 1023 (12.58) 365 (8.43) 103 (12.36) 3402 (9.71)
 Mother has AD 223 (28.96) 3329 (16.03) 25 (12.38) 1855 (22.82) 655 (15.13) 189 (22.69) 6276 (17.91)
 Sibling has AD 27 (3.51) 261 (1.26) 1 (0.5) 191 (2.35) 51 (1.18) 20 (2.4) 551 (1.57)
Marriage status, number (%)b
 Living with a partner 611 (79.35) 16,077 (77.4) 158 (78.22) 6295 (77.43) 3336 (77.04) 624 (74.91) 27,101 (77.35)
 Not living with a partner 65 (8.44) 1521 (7.32) 16 (7.92) 629 (7.74) 310 (7.16) 74 (8.88) 2615 (7.46)
Education, number (%)
 College/university degree or above 375 (48.7) 9656 (46.49) 88 (43.56) 3750 (46.13) 1978 (45.68) 398 (47.78) 16,245 (46.37)
 No college/university degree or above 350 (45.45) 9636 (46.39) 98 (48.51) 3855 (47.42) 2036 (47.02) 374 (44.9) 16,349 (46.66)
Social deprivation, number (%)
 Above the Townsend deprivation  index median 307 (39.87) 8750 (42.13) 79 (39.11) 3426 (42.14) 1755 (40.53) 334 (40.1) 14,651 (41.82)
 Below the Townsend deprivation  index median 463 (60.13) 12,001 (57.78) 123 (60.89) 4697 (57.77) 2568 (59.31) 499 (59.9) 20,351 (58.09)
Lifestyle factors, number (%)
 Smoking status
  Not current smoking 732 (95.06) 19,433 (93.56) 192 (95.05) 7603 (93.52) 4061 (93.79) 784 (94.12) 32,805 (93.63)
  Current smoking 38 (4.94) 1293 (6.23) 10 (4.95) 510 (6.27) 263 (6.07) 47 (5.64) 2161 (6.17)
 Doing regular physical activity
  Yes 586 (76.1) 15,593 (75.07) 153 (75.74) 6075 (74.72) 3265 (75.4) 603 (72.39) 26,275 (75)
  No 182 (23.64) 5043 (24.28) 49 (24.26) 1997 (24.56) 1043 (24.09) 224 (26.89) 8538 (24.37)
 Healthy diet
  Yes 408 (52.99) 10,133 (48.79) 90 (44.55) 4019 (49.43) 2063 (47.64) 398 (47.78) 17,111 (48.84)
  No 362 (47.01) 10,628 (51.17) 112 (55.45) 4105 (50.49) 2265 (52.31) 435 (52.22) 17,907 (51.11)
 Alcohol consumption
  Excessive alcohol consumption 203 (26.36) 5842 (28.13) 58 (28.71) 2346 (28.86) 1245 (28.75) 216 (25.93) 9910 (28.29)
  Moderate alcohol consumption 485 (62.99) 12,666 (60.98) 115 (56.93) 4876 (59.98) 2610 (60.28) 529 (63.51) 21,281 (60.74)
  Not current drinking 82 (10.65) 2251 (10.84) 29 (14.36) 907 (11.16) 474 (10.95) 88 (10.56) 3831 (10.93)
 Sleeping between 6 and 8 h
  Yes 342 (44.42) 9017 (43.41) 89 (44.06) 3645 (44.83) 1810 (41.8) 380 (45.62) 15,283 (43.62)
  No 426 (55.32) 11,706 (56.36) 113 (55.94) 4473 (55.02) 2507 (57.9) 451 (54.14) 19,676 (56.16)

aAll variables are measured at the baseline except the age at imaging.

bPercentiles do not add up to 1 due to missingness.