Table 1.
APOE-ε4 homozygote | APOE-ε3 homozygote | APOE-ε2 homozygote |
APOE-ε4/
APOE-ε3 |
APOE-ε2/
APOE-ε3 |
APOE-ε4/
APOE-ε2 |
Total | |
---|---|---|---|---|---|---|---|
Characteristicsa | (n = 770) | (n = 20,770) | (n = 202) | (n = 8130) | (n = 4330) | (n = 833) | (n = 35,035) |
Age at baseline, mean(sd)/median(range) | |||||||
54.2 (7.26) | 54.9 (7.46) | 54.7 (7.67) | 54.5 (7.38) | 55.0 (7.41) | 54.8 (7.55) | 54.8 (7.44) | |
55.0 [40.0, 69.0] | 55.0 [40.0, 70.0] | 55.0 [40.0, 69.0] | 55.0 [40.0, 70.0] | 56.0 [40.0, 70.0] | 55.0 [40.0, 70.0] | 55.0 [40.0, 70.0] | |
Age at brain imaging, mean(sd)/median(range) | |||||||
63.1 (7.30) | 63.8 (7.55) | 63.7 (7.88) | 63.3 (7.47) | 63.8 (7.50) | 63.7 (7.63) | 63.6 (7.53) | |
64.0 [47.0, 80.0] | 64.0 [45.0, 81.0] | 64.0 [46.0, 80.0] | 64.0 [46.0, 81.0] | 64.0 [45.0, 81.0] | 64.0 [47.0, 80.0] | 64.0 [45.0, 81.0] | |
Ethnicity, number (%) | |||||||
British | 725 (94.16) | 19,082 (91.87) | 187 (92.57) | 7535 (92.68) | 4002 (92.42) | 789 (94.72) | 32,320 (92.25) |
Others | 45 (5.84) | 1688 (8.13) | 15 (7.43) | 595 (7.32) | 328 (7.58) | 44 (5.28) | 2715 (7.75) |
Sex, number (%) | |||||||
Male | 420 (54.55) | 9929 (47.8) | 93 (46.04) | 3737 (45.97) | 2032 (46.93) | 374 (44.9) | 16,515 (47.14) |
Female | 350 (45.45) | 10,841 (52.2) | 109 (53.96) | 4393 (54.03) | 2298 (53.07) | 459 (55.1) | 18,520 (52.86) |
Disease status, number (%) | |||||||
Dementia | 0 (0) | 1 (0) | 1 (0.5) | 2 (0.02) | 2 (0.05) | 0 (0) | 6 (0.02) |
Not dementia | 770 (100) | 20,769 (100) | 201 (99.5) | 8128 (99.98) | 4328 (99.95) | 833 (100) | 35,029 (99.98) |
Family illness, number (%) | |||||||
Father has AD | 128 (16.62) | 1764 (8.49) | 19 (9.41) | 1023 (12.58) | 365 (8.43) | 103 (12.36) | 3402 (9.71) |
Mother has AD | 223 (28.96) | 3329 (16.03) | 25 (12.38) | 1855 (22.82) | 655 (15.13) | 189 (22.69) | 6276 (17.91) |
Sibling has AD | 27 (3.51) | 261 (1.26) | 1 (0.5) | 191 (2.35) | 51 (1.18) | 20 (2.4) | 551 (1.57) |
Marriage status, number (%)b | |||||||
Living with a partner | 611 (79.35) | 16,077 (77.4) | 158 (78.22) | 6295 (77.43) | 3336 (77.04) | 624 (74.91) | 27,101 (77.35) |
Not living with a partner | 65 (8.44) | 1521 (7.32) | 16 (7.92) | 629 (7.74) | 310 (7.16) | 74 (8.88) | 2615 (7.46) |
Education, number (%) | |||||||
College/university degree or above | 375 (48.7) | 9656 (46.49) | 88 (43.56) | 3750 (46.13) | 1978 (45.68) | 398 (47.78) | 16,245 (46.37) |
No college/university degree or above | 350 (45.45) | 9636 (46.39) | 98 (48.51) | 3855 (47.42) | 2036 (47.02) | 374 (44.9) | 16,349 (46.66) |
Social deprivation, number (%) | |||||||
Above the Townsend deprivation index median | 307 (39.87) | 8750 (42.13) | 79 (39.11) | 3426 (42.14) | 1755 (40.53) | 334 (40.1) | 14,651 (41.82) |
Below the Townsend deprivation index median | 463 (60.13) | 12,001 (57.78) | 123 (60.89) | 4697 (57.77) | 2568 (59.31) | 499 (59.9) | 20,351 (58.09) |
Lifestyle factors, number (%) | |||||||
Smoking status | |||||||
Not current smoking | 732 (95.06) | 19,433 (93.56) | 192 (95.05) | 7603 (93.52) | 4061 (93.79) | 784 (94.12) | 32,805 (93.63) |
Current smoking | 38 (4.94) | 1293 (6.23) | 10 (4.95) | 510 (6.27) | 263 (6.07) | 47 (5.64) | 2161 (6.17) |
Doing regular physical activity | |||||||
Yes | 586 (76.1) | 15,593 (75.07) | 153 (75.74) | 6075 (74.72) | 3265 (75.4) | 603 (72.39) | 26,275 (75) |
No | 182 (23.64) | 5043 (24.28) | 49 (24.26) | 1997 (24.56) | 1043 (24.09) | 224 (26.89) | 8538 (24.37) |
Healthy diet | |||||||
Yes | 408 (52.99) | 10,133 (48.79) | 90 (44.55) | 4019 (49.43) | 2063 (47.64) | 398 (47.78) | 17,111 (48.84) |
No | 362 (47.01) | 10,628 (51.17) | 112 (55.45) | 4105 (50.49) | 2265 (52.31) | 435 (52.22) | 17,907 (51.11) |
Alcohol consumption | |||||||
Excessive alcohol consumption | 203 (26.36) | 5842 (28.13) | 58 (28.71) | 2346 (28.86) | 1245 (28.75) | 216 (25.93) | 9910 (28.29) |
Moderate alcohol consumption | 485 (62.99) | 12,666 (60.98) | 115 (56.93) | 4876 (59.98) | 2610 (60.28) | 529 (63.51) | 21,281 (60.74) |
Not current drinking | 82 (10.65) | 2251 (10.84) | 29 (14.36) | 907 (11.16) | 474 (10.95) | 88 (10.56) | 3831 (10.93) |
Sleeping between 6 and 8 h | |||||||
Yes | 342 (44.42) | 9017 (43.41) | 89 (44.06) | 3645 (44.83) | 1810 (41.8) | 380 (45.62) | 15,283 (43.62) |
No | 426 (55.32) | 11,706 (56.36) | 113 (55.94) | 4473 (55.02) | 2507 (57.9) | 451 (54.14) | 19,676 (56.16) |
aAll variables are measured at the baseline except the age at imaging.
bPercentiles do not add up to 1 due to missingness.