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. Author manuscript; available in PMC: 2024 Jan 17.
Published in final edited form as: Hum Immunol. 2019 May 20;80(9):731–738. doi: 10.1016/j.humimm.2019.04.020

Fig 3. Hypothesis for effect of risk alleles in HLA-C on KD pathogenesis.

Fig 3.

We propose distinct mechanisms by which the risk alleles described here may affect KD susceptibility due to preferential binding of KD pathogen-derived peptides in the HLA-C antigen binding groove. The amino acids associated with the HLA-C risk allele may preferentially bind to KD antigen-derived peptides leading to T cell activation and arterial wall infiltration of CD8+ cytotoxic T cells. ER: endoplasmic reticulum