Fig. 1. The mTOR domain, sequence, and structure. (a) Domains and structure of ΔNmTOR/mLST8. (b) The sequence of the kinase domain of mTOR. There are several important inserted domains or motifs within the kinase domain of mTOR: the FRB domain (residues 2021–2118) in the N-lobe, and the LBE domain (residues 2258–2296), the kα9b-helix (residues 2425–2436), the NRD (residues 2430–2450), and the FATC domain (residues 2517–2549) in the C-lobe. (c) Conformation of the catalytic cleft of mTOR with the kα9b-helix and NRD inside the catalytic cleft, blocking the active site.
