Table 3.

Comparative features and advantages of therapeutic MAbs generated in different animals.

	Mouse	Rabbit	Camelid	Chicken
Evolutionary distance from humans, years8	91 million	91 million	92 million	310 million
Animal host class	mammalia	mammalia	mammalia	aves
Robust immune response against conserved proteins	-	-	-	+
Cross-reactive MAbs for preclinical models	-	+/-	+/-	+
Canonical IgG	+	+	+	+
HCDR3 length (aa)*	9.1±2.0 36	12.8±3.6 36	14.5±3.7 58	15.9±2.8 36
Long paratope with average HCDR3 >14 aa	-	-	+	+
Nanobodies from host	-	-	+	-
Immunization costs and animal logistics	$	$	$$$	$
Access to humanized animals	+	-	-	+
Diverse accessible B cell repertoire (spleen, marrow)	+	+	-	+

*Kabat numbering scheme used throughout paper. Any literature comparisons using alternate numbering schemes have been converted to Kabat. Camelid HCDR3 length is based on Llama VHH.