Table A2.

Seroconversion rate of anti-vi IgG ELISA response at week 24 for Dhulikhel Hospital – immunogenicity set.

Week 24 Post Vaccination	Vi-DT Group (Pooled Groups A+B+C)		Vi-TT Group		P-value†
	n/N	Seroconversion rate* (95% CI)	n/N	Seroconversion rate* (95% CI)
All Ages	314/317	99.05 (97.25, 99.68)	97/103	94.17 (87.87, 97.30)	.2396
Age Strata1	7/7	100.00 (64.57, 100.00)	3/3	100.00 (43.85, 100.00)	NA
Age Strata2	113/113	100.00 (96.71, 100.00)	37/38	97.37 (86.51, 99.53)	.2517
Age Strata3	194/197	98.48 (95.62, 99.48)	57/62	91.94 (82.47, 96.51)	.0209

N: number of total participants; n: number of participants seroconverted.

*Proportion of participants who had at least 4-fold rise anti-Vi antibody titers compared to baseline.

^†The p-value for all ages was derived using the generalized linear model for binomial distribution with group and strata as covariates. The p-value for each age strata was derived from Fisher’s exact test.