Thirumurthy 2011.

Methods	CBA study
Participants	1543 adult HIV+ persons, plus 54 caretakers and 67 children (Tamil Nadu, India) Index Group: 515 Control Group: 723 A total of 1238 participants were included in the final analysis.
Interventions	Intervention: Pharmacological, ART and home visits for ART adherence support Clinical care: routine medical care, diagnosis, and treatment of opportunistic infections Nutritional supplement: nutritional assessment, counseling, macronutrient/micronutrient supplements Home‐based care: home visits for encouraging participants to make monthly hospital visits, social service connection for income‐generating activities, legal services, and housing Control: All of the above except for ART and home visits for ART adherence support because CD4 counts were above 200 and ART was not indicated.
Outcomes	Employment: Whether participants took part in economic activities during the week prior to interview Number of hours they worked during the week prior to interview Individual income earned in the past 30 days Individual income earned in the past 6 months Health status: Body mass index CD4 cell count ART initiation date
Notes	***Participants were not required to be employed at the time of the study, however the study measured economic outcomes related to ART.
Risk of bias
Bias	Authors' judgement	Support for judgement
14. Blinding (Subjects)	Low risk	No blinding, however due to a dichotomous outcome of employment or non‐employment, this should not have affected the results.
15. Blinding (outcome assessors)	Low risk	No blinding. Objective outcomes that should have been unaffected by blinding.
16. Retrospective unplanned subgroup analysis	Low risk	No additional analysis.
17. Follow‐up	Low risk	Same time period. 68.66% present for interviews at 24 months.
18. Statistical tests	Unclear risk	Mean difference and standard error. Contacted authors for further interpertation but did not receive response.
19. Compliance	Unclear risk	Compliance to ART was not reported. However, ART participants did receive home visits to encourage ART adherence. ART adherence is required for survival, therefore compliance, although not monitored, is likely.
20. Outcome measures	Low risk	All previously determined outcomes were reported.
21. Selection Bias (population)	Low risk	Selected from same population. (Tamil Nadu Family Continuum Care Program)
22. Selection bias (time)	Low risk	Recruited at the same time.
23. Randomization	High risk	Non‐randomized study. Participants were predetermined by health status and CD4 counts.
24. Allocation concealment	Unclear risk	Non‐randomized.
25. Adjustment for confounding	High risk	Adjusted for gender. No adjustment for differences in disease severity. No adjustments for differences for SES. No adjustments for differences in age.
26. Incomplete outcome data	Unclear risk	34.34% attrition in index group addressed. No attrition data reported for controls.
Baseline comparability	Unclear risk	Female percentage was 42% in the index group and 65% in the reference group. Percentage of those who completed secondary education was 28% in the index group and 27% in the reference group. CD4 counts at baseline were 128.2 for the index group and 465.6 for the reference group.

ART: antiretroviral therapy
 CBA: controlled before‐after study
 HIV+ persons: persons living with HIV
 RCT: randomized controlled trial
 SES: socioeconomic status
 WHO: World Health Organization