Skip to main content
. 2023 Sep 26;110(1):238–252. doi: 10.1097/JS9.0000000000000774

Figure 4.

Figure 4

(A) Forest plot showing univariable survival analyses of LN memory cell enrichment scores. The enrichment score of each memory cell was dichotomized based on the median value. The HR (95% CI) and P value represent the HR and significance level of the survival advantage of the high- compared to the low-enrichment score group of each memory cell type. HR greater than 1 indicate a higher risk of progression. (B) Boxplot comparing LN memory cell enrichment scores between treatment response and nonresponse groups. The vertical axis represents the enrichment score calculated by ×Cell or CIBERSORT for various memory cell types. The horizontal axis shows the different memory cell types represented in the analysis. The blue boxes correspond to treatment response group, while the red boxes represent the nonresponse group. The P value for the group comparison is shown above each box. Patients who experienced a relapse within 6 months were categorized as the ‘response’ group, whereas those who did not were classified as the ‘non-response’ group. Patients with a follow-up duration of less than 6 months were excluded from the analysis. (C) Bubble plot showing the correlation between CD8+Tcm enrichment score and LN clearance, colored by RECIST1.1 response categories. Each bubble represents one patient, positioned on the plot according to their ×Cell-derived CD8+Tcm enrichment score and the number of resected LNs. The color of the bubble corresponds to the RECIST1.1 response category of the patient: purple for CR, red for PD, green for PR, and blue-gray for SD. (D) Kaplan–Meier curve plots to assess patient prognosis in CD8+Tcm high and low cohort (log-rank P value=0.0266). (E) The Sankey diagram visualizes the associations between LN CD8+ Tcm enrichment score, LN clearance, and RECIST1.1 response categories, using three vertical columns of connected ribbons. The leftmost column represents the ‘high LN CD8+Tcm’ and ‘low LN CD8+Tcm’ groups, divided by the median ×Cell enrichment score. The middle column displays the ‘DLN>16’ and ‘DLN≤16’ groups. The rightmost column illustrates the ‘CR/PR’ and ‘SD/PD’ groups, divided by RECIST1.1 criteria. The width of the ribbons corresponds to the patient count, with the ribbon color and column width indicating the degree of overlap between the groups. CR, complete response; HR, hazard ratio; LN, lymph node; Tcm, central memory T cells; Tem, effector memory T cells.