Table 4.

ICG and long-term (> 3 months) outcomes in liver transplants.

Study	Study variable(s)	Long-term outcome measure (n/N)	Prognostic value analysis test	Prognostic value for long-term outcome
Cherchi et al.28	Postoperative. ICG-PDR <16.0%/min on POD1 MELD score High volume of packed red blood cells on POD1 Hyperlactatemia on POD1 High bilirubin levels on POD1	One-year mortality One-year patient survival probability One-year overall Graft-Survival (55/77) Five-year patient survival	Univariate survival analysis, univariate regression and stepwise backward Cox multivariate regression model	Univariate Cox regression analysis. One-year mortality: ICG-PDR HR 0.92 (0.86–0.98), P <0.02; MELD HR 1.09 (1.02–1.16), P=0.01; Packed red blood cells HR 1.07 (1.00–1.15), P <0.04; Hyperlactatemia HR 1.65 (1.25–2.19), P <0.01; Bilirubin HR 1.14 (1.07–1.21), P <0.01. Multivariate Cox regression analysis. One-year mortality: ICG-PDR HR 0.92 (0.86–0.99), P <0.04; MELD HR 1.07 (1.01–1.15), P=0.02. One-year patient survival probability: ICG-PDR HR 3.67 (1.52–8.87), P <0.01. One-year overall Graft-Survival: ICG-PDR HR 3.35 (1.44–7.76), P <0.01. 5-year patient survival: ICG-PDR HR 2.84 (1.18–6.86), P <0.03.

HR, hazard ratio; ICG-PDR, indocyanine green plasma disappearance rate; MELD, Model for End-Stage Liver Disease; POD, postoperative day.