TABLE 2.
Univariate Analysis for the Difference Between Completed and Terminated Clinical Trials
| Factor | Completed Trial (n = 768) | Terminated Trial (n = 265) | P |
|---|---|---|---|
| Sex of the PI, No. (%) | .585 | ||
| Female | 102 (17.3) | 35 (15.4) | |
| Male | 487 (82.7) | 192 (84.6) | |
| Experience in the medical field, No. (%) | 19.6 (9.57) | 21.5 (9.94) | .056 |
| PI age, years | 59.0 (52.0; 65.0) | 59.0 (53.0; 64.0) | .640 |
| PI number of citations | 7,687 (2,865; 17,985) | 6,230 (2,101; 18,157) | <.001* |
| Funding source, No. (%) | |||
| Industrial | 404 (52.7) | 124 (46.8) | |
| NIH | 212 (27.7) | 75 (28.3) | |
| Other | 1 (0.13) | 1 (0.38) | |
| Private | 75 (9.79) | 15 (5.66) | |
| University | 74 (9.66) | 50 (18.9) | |
| Intervention, No. (%) | .020* | ||
| Device | 24 (3.15) | 7 (2.64) | |
| Medication | 602 (79.0) | 214 (80.8) | |
| Medication/surgery | 26 (3.41) | 15 (5.66) | |
| Medication/radiation | 19 (2.49) | 6 (2.26) | |
| Other | 53 (6.96) | 4 (1.51) | |
| Radiation | 23 (3.02) | 11 (4.15) | |
| Surgery | 15 (1.97) | 8 (3.02) | |
| No. of agents, No. (%) | <.001* | ||
| 1 | 300 (46.5) | 102 (43.6) | |
| 2 | 218 (33.8) | 80 (34.2) | |
| 3 | 83 (12.9) | 30 (12.8) | |
| More than 3 | 44 (6.82) | 22 (9.40) | |
| Phase, No. (%) | .005* | ||
| I | 36 (5.78) | 9 (4.02) | |
| II | 455 (73.0) | 190 (84.8) | |
| III | 113 (18.1) | 22 (9.82) | |
| IV | 19 (3.05) | 3 (1.34) | |
| Masking, No. (%) | .014* | ||
| None | 615 (81.3) | 236 (90.1) | |
| Single | 23 (3.04) | 3 (1.15) | |
| Double | 44 (5.82) | 11 (4.20) | |
| Triple | 37 (4.89) | 4 (1.53) | |
| Quadruple | 37 (4.89) | 8 (3.05) | |
| Centers, No. (%) | <.001* | ||
| Multi | 448 (60.3) | 110 (41.8) | |
| Single | 295 (39.7) | 153 (58.2) | |
| Country, No. (%) | .009* | ||
| HICs | 610 (96.8) | 250 (100) | |
| LMICs | 20 (3.17) | 0 (0.00) | |
| Sample, No. (%) | <.001* | ||
| Less than 50 | 355 (46.2) | 218 (82.3) | |
| More than 50 | 413 (53.8) | 47 (17.7) |
Abbreviations: HICs, high-income countries; LMICs, low- and middle-income countries; NIH, National Institutes of Health; PI, principal investigator.
*
Signifies statistical significance.