TABLE 3.
Multivariate Analysis for the Difference Between Completed and Terminated Clinical Trials
| Multivariate Analysis | OR (95% CI) | P |
|---|---|---|
| Funding source | ||
| Industrial | Ref | Ref |
| NIH | 1.15 (0.83 to 1.60) | .402 |
| Other | 3.25 (0.08 to 127) | .472 |
| Private | 0.66 (0.35 to 1.16) | .150 |
| University | 2.20 (1.45 to 3.32) | <.001* |
| Intervention | ||
| Device | Ref | Ref |
| Medication | 1.20 (0.53 to 3.09) | .675 |
| Medication/surgery | 1.94 (0.69 to 5.95) | .215 |
| Medication/radiation | 1.08 (0.29 to 3.89) | .901 |
| Other | 0.27 (0.06 to 0.99) | .049 |
| Radiation | 1.62 (0.53 to 5.18) | .398 |
| Surgery | 1.80 (0.53 to 6.30) | .344 |
| No. of agents | ||
| 1 | Ref | Ref |
| 2 | 1.08 (0.77 to 1.52) | .661 |
| 3 | 1.07 (0.65 to 1.70) | .794 |
| More than 3 | 1.47 (0.83 to 2.56) | .183 |
| Phase | ||
| I | Ref | Ref |
| II | 1.65 (0.81 to 3.73) | .176 |
| III | 0.77 (0.33 to 1.93) | .568 |
| IV | 0.65 (0.13 to 2.56) | .557 |
| Masking | ||
| None | 1.52 (0.80 to 3.15) | .213 |
| Single | 0.54 (0.11 to 1.98) | .373 |
| Double | Ref | Ref |
| Triple | 0.45 (0.11 to 1.45) | .185 |
| Quadruple | 0.87 (0.30 to 2.41) | .789 |
| Centers | ||
| Multi | Ref | Ref |
| Single | 2.11 (1.59 to 2.81) | <.001* |
| Sample | ||
| Less than 50 | Ref | Ref |
| More than 50 | 0.19 (0.13 to 0.26) | <.001* |
Abbreviations: NIH, National Institutes of Health; OR, odds ratio.
*
Signifies statistical significance.