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Number of dose-finding trials implementing different designs over time. Data from trials using the TITE-CRM with cycle information consideration are merged with those using the TITE-CRM, as the former is a modified version of the latter. RED, rapid enrollment design; TITE-BOIN, time-to-event Bayesian optimal interval design; TITE-CCD, TITE cumulative cohort design; TITE-CRM, TITE continuous reassessment method.
