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. Author manuscript; available in PMC: 2024 Jan 17.
Published in final edited form as: Sci Transl Med. 2023 Apr 26;15(693):eabp9528. doi: 10.1126/scitranslmed.abp9528

Fig. 5. Cluster B clone profiles encompass IPF scRNA-seq populations.

Fig. 5.

(A) Scatter plot with marginal histograms comparing fold change of differentially expressed genes from RNA-seq data of sorted epithelial cells from IPF lung (20) with cluster A and cluster B clones from IPF library. (B) Expression heatmap of consistent genes identified in sorted IPF epithelial cells (20) with the cluster A and cluster B IPF clones. (C) Similarity matrix between expression signatures of populations identified by four scRNA-seq studies of IPF lungs (20, 26–28) and IPF cluster A and cluster B clones. (D) Common genes identified by at least two scRNA-seq studies and IPF cluster B clone. (E) Histogram of percentage of overlap in gene expression between epithelial populations emerging in murine lung after bleomycin and IPF cluster A and cluster B clones. (F) Consistent differentially expressed genes from both murine bleomycin studies and IPF cluster A and cluster B clones.