Scheme 2.
Synthesis of Imidazo[2,1-i]purinone Derivatives and Ring-Enlarged Analoguesa
a Reagents: (i) P2S5, pyridine, 8 h, Δ. (ii) MeI, NaOH/EtOH, 1 h, room temperature. (iii) Amino alcohol, DMSO, 1 h, 150 °C. (iv) SOCl2, 1 h Δ.
Synthesis of Imidazo[2,1-i]purinone Derivatives and Ring-Enlarged Analoguesa
a Reagents: (i) P2S5, pyridine, 8 h, Δ. (ii) MeI, NaOH/EtOH, 1 h, room temperature. (iii) Amino alcohol, DMSO, 1 h, 150 °C. (iv) SOCl2, 1 h Δ.