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. Author manuscript; available in PMC: 2024 Jan 17.
Published in final edited form as: J Med Chem. 2002 Aug 1;45(16):3440–3450. doi: 10.1021/jm011093d

Table 1.

Intermediate Xanthines Used for the Preparation of Tricyclic Purinone Derivatives

graphic file with name nihms-1958395-t0005.jpg
compd R1 R2 R4 mp1 (°C) (lit. mp) yield1 (%)
11a CH3 H CH3 290–295 a
11b H H benzyl >250 (>300)34 90
11c CH3 H H >270 (>330)16 75
11d H phenyl CH3 >250 (>360)35 46
11e CH3 phenyl H >250 80
11f CH3 phenyl CH3 >250 (300)36 85
11g H styryl CH3 >270 80
11h CH3 styryl CH3 >270 88
a

Theobromine (11a) was commercially available.