TABLE 2.
Modifications | Examples | Effects on potencya |
---|---|---|
Base modifications | ||
2-Thioether | 2-MeSATP | ↑ |
2-Hexylthio ATP | ↑ | |
8-Substitution | 8-Br-ATP | ↓ or no change |
8-(6-Aminohexylamino) ATP | ↓ | |
N6 | N6-methyl ATP | No change |
Ribose modifications | ||
Deoxy | 2′-Deoxy ATP | ↓ |
3′-Deoxy ATP | ↓ | |
2′-,3′-Dideoxy ATP | ↓ | |
Other substitutions | 3′-Amino, 3′-deoxy ATP | ↑ |
Adenosine 3′-phosphate 5′-phosphosulfate | ↑, partial agonist | |
3′-Benzylamino 3′-deoxy ATP | ↓ | |
Phosphate substitutions | ||
Thiophosphate | ATPγS | ↑ |
Methylene bridge | αβMeATP | ↓ |
βγMeATP | ↓ | |
Imino bridge | AppNHp | No change |
Diphosphates | ||
ADP | ↑ or similar potency | |
ADPβS | ↑ | |
2-Thioether diphosphates | ↑ | |
Monophosphates | ||
AMP | Inactive | |
2-(5-Hexenylthio) AMP | ↑ |
Relative to ATP.