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. 2024 Jan 2;5(1):100544. doi: 10.1016/j.xinn.2023.100544

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© 2023 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Verification of AD stage-dependent dysregulated proteins in the validation cohort

(A) Heatmap of the levels of the validated core dysregulated CSF proteins in different stages of AD.

(B) Expression level change (Z scored original value) of 4 selected CSF proteins dysregulated over the course of AD progression.

(C) Heatmap of the levels of the validated core dysregulated serum proteins in different stages of AD.

(D) Expression level change (Z scored original value) of 4 selected serum proteins dysregulated over the course of AD progression.