Figure S1.

Endothelial super-enhancers are enriched with EC transcription factor binding sites and cardiovascular disease (CVD) GWAS SNPs and physically contact with more promoters compared with typical-enhancers. (A) Histograms demonstrating a higher percentage of endothelial super-enhancers (red) than typical-enhancers (gray) containing denser binding sites for transcription factors ERG, JUN, JUNB, and p65. X-axis: transcription factor binding sites density (the ChIP-seq tag counts at each enhancer locus normalized to that enhancer length). Y-axis: percentage of enhancers. (B) The top GWAS disease classes associated with endothelial super-enhancers-harboring SNPs, ranked by −log₁₀(q value) determined by binomial test. (C) PCHi-C in HAECs demonstrate that endothelial super-enhancers form significantly more interactions with promoters than typical-enhancers do. ****P value ≤0.0001 was determined by two-sided Student’s t test.