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. 2024 Jan 3;625(7995):566–571. doi: 10.1038/s41586-023-06873-0

Fig. 2. The second-generation lead zosurabalpin demonstrates low lipid plasma precipitation.

Fig. 2

a, The drug lipophilicity (AlogP) of basic MCPs and zwitterionic MCPs in correlation with plasma precipitation. The standard of care (SoC) antibiotics and their AlogP lipophilicities are described in Extended Data Table 5. b, The chemical structure of the second-generation tethered macrocyclic peptides: zwitterions RO7202110 and zosurabalpin (ZAB).