Extended Data Table 1.

Summary of DMPK & in vitro safety profile of RO7036668, RO7075573, RO7202110, zosurabalpin

¹ > 30% inhibition, see Supplementary Table 1 for details; ²Fraction unbound in mouse plasma; ³1 mg/kg IV; ⁴Scores from 0 (no precipitation) to 3 (strong precipitation), ⁵Concentrations of formulated compound from 0.06–4 mg/mL tested; ⁶Concentrations of formulated compound from 0.125–2 mg/mL tested. MNT, micronucleus test; Cl, Clearance; Vss, volume of distribution at steady state; t_1/2, terminal plasma half-life; n.d., not determined.