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. 2024 Jan 17;14:1464. doi: 10.1038/s41598-024-51397-w

Figure 4.

Figure 4

Inhibition of mucus secretion by niclosamide and benzbromarone in airways of asthmatic mice. (A) Alcian blue staining of mucus in trachea and bronchioles from control animals and OVA-treated asthmatic mice stained by haematoxylin & eosin. Intratracheal instillation of 30 µM niclosamide (Niclo) or 30 µM benzbromarone (Benz) dissolved in 100 µl saline, or 100 µl saline only (OVA) for 5 consecutive days. Bars = 20 µm. (B) Summary of alcian blue staining of airway mucus (blue colour intensity per section) in trachea (n = 5 animals/n = 16–19 sections analysed for each animal) and bronchioles (n = 5 animals/n = 16–19 sections analysed for each animal). Mean ± SEM. #Significant difference when compared to control (p < 0.05; ANOVA & post hoc Bonferroni).