Fig. 2. Regional association plot of locus 7 at Xq21.1.

Comparison of association plots of eGFR at locus 7 at Xq21.1 between analysis groups overall, males and females. The same genomic region is displayed for overall (a), female (b) and male analysis (c), respectively. The y-axes report the (negative) log₁₀(p-values) of the associations (β coefficient of additive genetic effect in linear regression analysis, two-sided). The primarily identified index variant rs3850318 showed no sex-dimorphism and is confined to the same haploblock as the best associated SNP in males (c). Colocalization analysis revealed an independent association (PP(H3) = 95%), which is significant in females only (rs149995096) and corresponding to a neighboring haploblock (b). Subgroup-specific top-hits are depicted as filled circles or marked as empty circles (blue = overall, green = male, magenta = female). In red, we highlight the candidate genes for this locus (a).