Table 2.
IC50 values of ISV inhibition for early and late exposure window
| TKI compound | 3–96 hpf exposure | 24–96 hpf exposure | Predicted baseline | ||
|---|---|---|---|---|---|
| LC50 (µM) | IC50 (µM) | LC50 (µM) | IC50 (µM) | LC50 (µM) | |
| SU4312 | 2.11 ± 0.22 | 2.30 ± 0.42 | NA | 2.59 ± 0.60 | 33.5 |
| PTK787 | 0.68 ± 0.51 | 0.09 ± 0.04 | NA | 0.14 ± 0.03 | 29,171 |
| Sorafenib | 2.80 ± 0.31 | 1.37 ± 0.1 | NA | 1.36 ± 0.24 | 0.55 |
| SU5416 | 0.89 ± 0.42 | NA | 1.93 ± 0.83 µM | 2.10 ± 0.35 | 1395 |
The predicted baseline toxicity refers to the LC50 of fish embryos. Numbers indicate the modelled effect concentration ± 95% confidence intervals