Table 5.

Reverse causal association between autoimmune hypothyroidism and gut microbiota.

Exposure	Outcome	Methods	OR	CILower	CIUpper	P
Autoimmune hypothyroidism	Phylum.Actinobacteria	IVW	1.009	0.978	1.042	0.563
		Weighted median	1.017	0.968	1.069	0.507
		MR Egger	0.993	0.921	1.070	0.854
Autoimmune hypothyroidism	Genus.Intestinimonas	IVW	1.001	0.963	1.041	0.954
		Weighted median	0.995	0.938	1.056	0.878
		MR Egger	0.964	0.879	1.056	0.429
Autoimmune hypothyroidism	Genus.DefluviitaleaceaeUCG011	IVW	0.928	0.865	0.996	0.486
		Weighted median	0.993	0.881	1.120	0.911
		MR Egger	0.960	0.815	1.132	0.632
Autoimmune hypothyroidism	Genus.Eggerthella	IVW	1.025	0.964	1.089	0.428
		Weighted median	0.983	0.891	1.085	0.731
		MR Egger	0.932	0.809	1.074	0.334
Autoimmune hypothyroidism	Family. Defluviitaleaceae	IVW	0.990	0.943	1.039	0.692
		Weighted median	0.987	0.916	1.064	0.738
		MR Egger	1.022	0.912	1.145	0.692
Autoimmune hypothyroidism	Genus. Subdoligranulum	IVW	1.022	0.987	1.057	0.220
		Weighted median	1.008	0.954	1.066	0.773
		MR Egger	0.965	0.892	1.045	0.220
Autoimmune hypothyroidism	Genus. RuminococcaceaeUCG011	IVW	0.989	0.943	1.038	0.665
		Weighted median	0.991	0.917	1.070	0.812
		MR Egger	1.020	0.911	1.141	0.736