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Effect of G12C inhibitors on the function of mutant KRAS protein [11]. (A) Function of the G12C mutated KRAS protein. (B) Function of the G12C mutated KRAS protein bound to inhibitors. Ad, adagrasib; GAP, GTP-ase activating protein; GEF, guanin nucleotide exchange factor; GFR, growth factor receptor; So, sotorasib.
