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. 2024 Jan 4;29:1611580. doi: 10.3389/pore.2023.1611580

TABLE 1.

Biochemical characteristics of KRAS mutant proteins [11].

KRAS Wild type (G12) G12C G12D G12V
GTP affinity High High High High
GDP/GTP exchange Fast Medium Slow Slow
GTP-ase activity High High Decreased Lost
GAP sensitivity High Lost Lost Lost
(B)RAF affinity High High Decreased Decreased

GAP, GTP-ase activating protein.