TABLE 1.
KRAS | Wild type (G12) | G12C | G12D | G12V |
---|---|---|---|---|
GTP affinity | High | High | High | High |
GDP/GTP exchange | Fast | Medium | Slow | Slow |
GTP-ase activity | High | High | Decreased | Lost |
GAP sensitivity | High | Lost | Lost | Lost |
(B)RAF affinity | High | High | Decreased | Decreased |
GAP, GTP-ase activating protein.