TABLE 6.
Chitosan-based nanocomposites in different drug delivery systems.
| Chitosan-based nanocomposites | Loaded drugs | Routes of administration | Main findings | References |
|---|---|---|---|---|
| N-trimethyl chitosan coated nanocomplexes | Gemcitabine | Oral delivery | Enhanced drug bioavailability, improved its therapeutic effect, and inhibited tumor growth | Chen et al. (2021) |
| Chitosan nanoparticles | Hesperidin | Nasal delivery | Improved cellular absorption and reduced cytokine storm syndrome in the lungs | Jin et al. (2021) |
| N-Trimethyl chitosan nanoparticles | Flurbiprofen | Ocular delivery | Delayed drug liberation and enhanced its therapeutic efficacy | Shinde et al. (2019) |
| Chitosan nanoparticles | Metformin | Oral delivery | Increased systemic delivery and therapeutic efficacy in polycystic kidneys | (J. Wang et al., 2021) |
| Carboxymethyl chitosan nanoparticles | Basic fibroblast growth factor | Transdermal delivery | Improved dosing efficiency and prevented the drug from remaining on the skin surface | Xie et al. (2022) |
| Chitosan nanoparticles loaded nanofiber | Benzydamine | Vaginal delivery | Increased mucoadhesion and provided higher permeation through the vaginal tissue | Tuğcu-Demiröz et al. (2021) |
| Chitosan hydrogel | Ibuprofen | Nasal delivery | Improved drug solubility and accelerated transport through nasal epithelial cells | Gholizadeh et al. (2019) |
| N-trimethyl chitosan coated nanoparticles | Vitexin | Oral delivery | Promoted drug absorption and improved its antioxidant activity | Li S et al. (2022) |
| Glycol-chitosan oxidize hyaluronic acid hydrogel film | Levofloxacin | Ocular delivery | Showed progressive drug release and significantly reduced various inflammatory cytokines | Bao et al. (2021) |
| Chitosan nanoparticles | Acyclovir | Vaginal delivery | Enhanced cellular absorption in the vaginal mucosa and prolonged drug liberation | Deshkar et al. (2021) |
| Thiolated chitosan microneedle patch | Tacrolimus | Transdermal delivery | Enhanced availability and sustained liberation over a longer period. Better penetration into the dermis, without rupture | Ahmad et al. (2020b) |
| N-Trimethyl chitosan nanoparticles | Metronidazole | Periodontal delivery | Enhanced antibacterial activity against periodontal infections | Garg and Tirgar (2022) |
| Chitosan-ethyl cellulose microspheres | Domperidone | Nasal delivery | Improved the bioavailability by avoiding its first-pass metabolism and regulated drug concentration in the blood | Zafar et al. (2021) |