TABLE 1.

Summary of key literature reviewed on donor-derived cell-free DNA for subclinical rejection.

Authors	Study design	Number of samples	Results
[2]	Retrospective analysis on biorepository samples, Single center	114 biopsies	For any subAR (AUROC 0.89, PPV 0.55, NPV 0.97)
		13 rejections
		101 no rejection
[7]	Prospective observational (post hoc analysis), Multicenter	428 biopsies	For any subAR (AUROC 0.72, PPV 0.56, NPV 0.84)
		103 rejections
		325 no rejection
[8]	Retrospective cross-sectional, Single center	37 biopsies	For any subAR (sensitivity 0, specificity 0.89, PPV 0, NPV 0.71)
		10 rejections
		27 no rejection

AUROC, area under the receiver operating characteristic curve; subAR, subclinical rejection; NPV, negative predictive value; PPV, positive predictive value.