TABLE 1.

Effect estimation of the association between meaningful gut microbiota and risk of GBM in MR analysis. Abbreviations: GBM, glioblastoma; MR, Mendelian randomization analysis; SNPs, Number of single nucleotide polymorphism. CI, confidence interval; OR, odds ratio; P _FDR, p-value was calculated by the Benjamini-Hochberg method.

Gut microbiota	Outcome	SNPs	Methods	OR (95% CI)	p-value	P FDR
family.Peptostreptococcaceae	GBM
		13	MR-Egger	2.34 (0.10–52.17)	0.603
		13	Weighted median	6.42 (1.09–37.71)	0.040
		13	IVW	3.83 (1.02–14.35)	0.046	0.566
family.Ruminococcaceae	GBM
		9	MR-Egger	0.02 (3.89E-4-0.72)	0.070
		9	Weighted median	0.08 (0.01–0.79)	0.031
		9	IVW	0.04 (0.01–0.19)	9.51E-5	0.003
genus.Anaerostipes	GBM
		13	MR-Egger	2.94 (0.01–1058.94)	0.727
		13	Weighted median	0.34 (0.04–2.78)	0.312
		13	IVW	0.16 (0.03–0.83)	0.029	0.680
genus.Eubacterium brachy group	GBM
		10	MR-Egger	0.96 (0.03–36.27)	0.984
		10	Weighted median	4.70 (1.46–15.14)	0.009
		10	IVW	2.85 (1.16–7.01)	0.023	0.680
genus.Faecalibacterium	GBM
		18	MR-Egger	0.31 (0.02–4.96)	0.434
		18	Weighted median	0.18 (0.02–1.52)	0.115
		18	IVW	0.16 (0.04–0.65)	0.011	0.632
genus.Lachnospiraceae UCG004	GBM
		24	MR-Egger	0.09 (1.42E-4-61.80)	0.491
		24	Weighted median	0.32 (0.04–2.53)	0.281
		24	IVW	0.20 (0.04–0.96)	0.045	0.758
genus.Phascolarctobacterium	GBM
		12	MR-Egger	0.03 (1.20E-5-75.19)	0.414
		12	Weighted median	0.65 (0.08–5.60)	0.694
		12	IVW	0.19 (0.04–0.93)	0.041	0.680
genus.Prevotella7	GBM
		27	MR-Egger	0.82 (0.01–92.06)	0.936
		27	Weighted median	0.28 (0.10–0.84)	0.023
		27	IVW	0.30 (0.13–0.68)	0.004	0.458
genus.Streptococcus	GBM
		10	MR-Egger	0.02 (6.59E-5- 3.57)	0.159
		10	Weighted median	0.27 (0.03–2.16)	0.215
		10	IVW	0.21 (0.05–0.97)	0.046	0.758